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The Impact of HLA-A29 Homozygosity and of the Second HLA-A Allele on Susceptibility and Severity of Birdshot Chorioretinitis.

Investigative ophthalmology & visual science - 4 Nov 2024

Loeliger Jordan, Lhotte Romain, Gelfman Sahar, Stahl Eli A, Monnet Dominique, Clichet Valentin, Imikirene Linda, Kecili Souhila, Taupin Jean-Luc, Tabary Thierry, Cohen Jacques H M, Brézin Antoine P

Abstract excerpt

Purpose: HLA-A29 is the main susceptibility factor for birdshot chorioretinitis (BSCR). Our study assessed the impact of the second HLA-A allele alongside HLA-A29 on BSCR severity and susceptibility, focusing on HLA-A29 homozygous patients and those with alleles from the HLA-Aw19 group. Methods: We included 120 additional cases to our previous analysis of 286 patients with BSCR, all HLA-A29 positive. Patients...

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Identifiers

PMID: 39570638
DOI: 10.1167/iovs.65.13.47
PMCID: PMC11585056

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