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Article

Genetic dissection of estrogen receptor signaling in vivo.

Ernst Schering Foundation symposium proceedings - 1 Jan 2006

Wintermantel T M, Elzer J, Herbison A E, Fritzemeier K H, Schütz G

Abstract excerpt

The multiple actions of estrogen in mammalian physiology are brought about, on a molecular level, by several signaling pathways, and mediated by at least two receptors-estrogen receptor (ER) alpha and beta. Analysis of knock-out mice devoid of either or both receptor isoforms revealed the essential function of estrogen receptor alpha in female reproduction, as ERalpha deficiency leads to a complex endocrine...

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PMID: 17824170
DOI: 10.1007/2789_2006_015

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