Article
Update on animal models developed for analyses of estrogen receptor biological activity.
The Journal of steroid biochemistry and molecular biology - 1 Sept 2003
Korach Kenneth S, Emmen Judith M A, Walker Vickie R, Hewitt Sylvia C, Yates Mariana, Hall Julie M, Swope Deborah L, Harrell Joshua C, Couse John F
Abstract excerpt
Targeted disruption of the different ER genes has generated experimental animal models that are very useful in evaluating the distinct and cooperative roles of the two estrogen receptors, ERalpha and ERbeta, in reproductive but also non-reproductive tissues of both sexes. Phenotypic analysis has provided definitive experimental findings for estrogen receptor mediated physiological actions, involving ERalpha in...
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