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Article

NFAR-1 and -2 modulate translation and are required for efficient host defense

12 Mar 2008

Abstract excerpt

We report here that the alternatively spliced nuclear factors associated with double-stranded RNA, NFAR-1 (90 kDa) and -2 (110 kDa), are involved in retaining cellular transcripts in intranuclear foci and can regulate the export of mRNA to the cytoplasm. Furthermore, the NFAR proteins were found to remain associated with exported ribonucleoprotein complexes. Loss of NFAR function, which was embryonic-lethal,...

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PMID: 18337511
DOI: 10.1073/pnas.0711222105

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