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Article

Myotilin overexpression enhances myopathology in the LGMD1A mouse model.

Muscle & nerve - 1 May 2008

Garvey Sean M, Liu Yutao, Miller Sara E, Hauser Michael A

Abstract excerpt

Missense mutations in the myotilin gene cause limb-girdle muscular dystrophy type 1A (LGMD1A). We set out to examine the effect of overexpression of wild-type myotilin in an LGMD1A mouse model by crossing wild-type and mutant transgenic mice. Compared to single-transgenic mutant mice, double-transgenic mice overexpressing myotilin showed more severe muscle degeneration, enhanced myofibrillar aggregation, and...

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Identifiers

PMID: 18335471
DOI: 10.1002/mus.20994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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