Article

Muscle-specific increased expression of <i>JAG1</i> improves skeletal muscle phenotype in dystrophin-deficient mice

2025-03-14

Abstract excerpt

Therapeutic strategies for Duchenne Muscular Dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function. The beneficial effects of the overexpression of Jagged-1 were described in escaper golden retriever muscular dystrophy (GRMD) dogs that had a near-normal life and validated in dystrophin-deficient zebrafish (1). To...

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Literature Corpus work: 52fb292d-6450-5bed-8f29-d26324145477
DOI: 10.1101/2025.03.12.642857

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