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Article

Human leucocyte antigen and TNFalpha polymorphism association in microscopic colitis.

European journal of gastroenterology & hepatology - 1 Apr 2008

Koskela Ritva M, Karttunen Tuomo J, Niemelä Seppo E, Lehtola Juhani K, Ilonen Jorma, Karttunen Riitta A

Abstract excerpt

OBJECTIVES: Coeliac disease (CD) is common in patients with microscopic colitis (MC). The human leucocyte antigen (HLA)-DR3-DQ2 haplotype is strongly associated with CD, and there is evidence for an association with MC. We analysed the genetic background of MC by assessing the haplotypes of HLA-DR3-DQ2 and HLA-DR4-DQ8. In addition, TNFalpha gene polymorphism (-308) associated with susceptibility to several...

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PMID: 18334870
DOI: 10.1097/MEG.0b013e3282f2468d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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