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Article

Adaptation to high altitude in Sherpas: association with the insertion/deletion polymorphism in the Angiotensin-converting enzyme gene.

Wilderness & environmental medicine - 1 Jan 2008

Droma Yunden, Hanaoka Masayuki, Basnyat Buddha, Arjyal Amit, Neupane Pritam, Pandit Anil, Sharma Dependra, Ito Michiko, Miwa Naoyuki, Katsuyama Yoshihiko, Ota Masao, Kubo Keishi

Abstract excerpt

OBJECTIVE: Sherpas are well-known for their physical strength at high altitudes. They adapt to high altitude so well that little acute or chronic mountain sickness has been documented in them. The possible genetic basis for this adaptation is, however, unclear. The objective of this study was to elucidate the genetic background underlying this characteristic among Sherpas with respect to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutagenesis, Insertional

Share to Peptidyl-Dipeptidase A

Source

Identifiers

PMID: 18333655
DOI: 10.1580/06-WEME-OR-073.1

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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