Article
Insertion/deletion polymorphism of the angiotensin I-converting enzyme gene and arterial oxygen saturation at high altitude.
American journal of respiratory and critical care medicine - 1 Aug 2002
Woods David R, Pollard Andrew J, Collier David J, Jamshidi Yalda, Vassiliou Vassilis, Hawe Emma, Humphries Steve E, Montgomery Hugh E
Abstract excerpt
There is a significant genetic influence on arterial oxygen saturation (Sa(O(2))) in high-altitude (HA) residents. It is not known whether this is true of lowlanders ascending to HA. The I allele of the angiotensin-converting enzyme (ACE) gene is associated with low ACE activity and elite endurance performance. An excess of the I allele has also been reported in South American natives living over 3,000 m and...
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