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Article

Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU

22 Dec 2004

Abstract excerpt

Vaso-occlusion is a hallmark of sickle cell disease. Agonist-induced activation of sickle red blood cells (SS RBCs) promotes their adhesion to vascular proteins, potentially contributing to vasoocclusion. Previously, we described a cyclic adenosine monophosphate (cAMP)-dependent increase in SS RBC adhesion to laminin. Here, we investigated whether Rap1, a small guanosine triphosphatase (GTPase) known to promote...

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Identifiers

PMID: 15613546
DOI: 10.1182/blood-2004-07-2881

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