Article
Estimating ethnic admixture from pedigree data.
American journal of human genetics - 1 Mar 2008
Sinsheimer Janet S, Plaisier Christopher L, Huertas-Vazquez Adriana, Aguilar-Salinas Carlos, Tusie-Luna Teresa, Pajukanta Päivi, Lange Kenneth
Abstract excerpt
This paper introduces a likelihood method of estimating ethnic admixture that uses individuals, pedigrees, or a combination of individuals and pedigrees. For each founder of a pedigree, admixture proportions are calculated by conditioning on the pedigree-wide genotypes at all ancestry-informative markers. These estimates are then propagated down the pedigree to the nonfounders by a simple averaging process. The...
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