Article
MspA Porin-Gold Nanoparticle Assemblies: Enhanced Binding through a Controlled Cysteine Mutation.
Nano letters - 1 Apr 2008
Dani Raj Kumar, Kang Myungshim, Kalita Mausam, Smith Paul E, Bossmann Stefan H, Chikan Viktor
Abstract excerpt
In this study, the interactions of two gold nanoparticles of different sizes (average diameters of 3.7 +/- 2.6 and 17 +/- 3 nm) with octameric mycobacterial porin A from Mycobacterium smegmatis (MspA) and a mutant of MspA featuring a cysteine mutation in position 126 (Q126C) are investigated. From the observation of enhanced photoluminescence quenching, it is inferred that the presence of eight cysteines in the...
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