Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C677T methylene-H4-folate-reductase variant decreases binocular accommodation.

Optometry and vision science : official publication of the American Academy of Optometry - 1 Mar 2008

Krumdieck Carlos L, Fernandez Jose R, Desmond Renee A, Kleinstein Robert N, Shipp Melvin D, Prince Charles W

Abstract excerpt

PURPOSE: The C677T polymorphism of methylene tetrahydrofolate reductase (MTHFR) lowers the activity of this enzyme, producing moderate elevation of blood levels of homocysteine (Hcy) and lowering the levels of 5-methyl-tetrahydro-folic acid (5-MeTHFA), methionine (Meth), and S-adenosylmethionine (SAM). In this study we examined 100 apparently normal subjects of both sexes (average age 25.6 +/- 4.25) for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Folic Acid
Share to MTHFR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genotype

Share to Homocysteine

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymerase Chain Reaction

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 18317335
DOI: 10.1097/OPX.0b013e3181643e97

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

C677T methylene-H4-folate-reductase variant decreases binocular accommodation.PMID 18317335Read ↗

Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis.Semantic proximity Read ↗

Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis.Semantic proximity Read ↗

C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma.Semantic proximity Read ↗

Methylenetetrahydrofolatereductase (MTHFR) 677C>T polymorphism and open angle glaucoma.Semantic proximity Read ↗

Association of MTHFR C667T Polymorphism, Homocysteine, and B Vitamins with Senile Cataract.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase 677 C-T and homocysteine levels in Turkish patients with pseudoexfoliation.Semantic proximity Read ↗

Homocysteine and related genetic polymorphisms in Down's syndrome IQ.Semantic proximity Read ↗

Search for correlations between genotypes and electrophysiological patterns in migraine: the MTHFR C677T polymorphism and visual evoked potentials.Semantic proximity Read ↗

Effect of L-Methylfolate Supplementation on Sleep for Patients with Reduced Methylenetetrahydrofolate Reductase Activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.