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Article

Homocysteine and related genetic polymorphisms in Down's syndrome IQ.

Journal of neurology, neurosurgery, and psychiatry - 1 May 2005

Guéant J-L, Anello G, Bosco P, Guéant-Rodríguez R-M, Romano A, Barone C, Gérard P, Romano C

Abstract excerpt

OBJECTIVE: Down's syndrome (DS) is the most frequent genetic cause of Alzheimer-type dementia. Its metabolic phenotype involves an increased trans-sulphuration of homocysteine. The aim of the present study was to investigate the influence of homocysteinaemia (t-Hcys), folate, vitamin B(12), and related polymorphisms on intelligence quotient (IQ) in DS. METHODS: The IQ of 131 patients with trisomy 21 from a...

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Identifiers

PMID: 15834031
DOI: 10.1136/jnnp.2004.039875
PMCID: PMC1739618

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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