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Article

Transcription factor AP-1 regulates TGF-beta(1)-induced expression of aldose reductase in cultured human mesangial cells.

Nephrology (Carlton, Vic.) - 1 Jun 2008

Jiang Tao, Qu Jie J, Nishinaka Toru, Zhang Nong

Abstract excerpt

AIM: The previous studies demonstrated that transforming growth factor-beta(1) (TGF-beta(1)) could upregulate the expression of aldose reductase (AR). The aim of this study is to clarify (investigate) the mechanism of TGF-beta(1)-induced AR expression. METHODS: Real-time polymerase chain reaction and western blot were used to analyse the AR expression in mRNA and protein levels in human mesangial cells, and...

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PMID: 18315703
DOI: 10.1111/j.1440-1797.2007.00913.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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