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Article

Role of CREB1 and NF{kappa}B-p65 in the down-regulation of renin gene expression by tumor necrosis factor {alpha}.

The Journal of biological chemistry - 1 Jul 2005

Todorov Vladimir T, Völkl Simon, Friedrich Jürgen, Kunz-Schughart Leoni A, Hehlgans Thomas, Vermeulen Linda, Haegeman Guy, Schmitz M Lienhard, Kurtz Armin

Abstract excerpt

Tumor necrosis factor-alpha (TNFalpha) is a potent inhibitor of renin gene expression in renal juxtaglomerular cells. We have found that TNFalpha suppresses renin transcription via transcription factor NFkappaB, which targets a cAMP responsive element (CRE) in the renin promoter. Here we aimed to further clarify the role of NFkappaB and the canonical CRE-binding proteins of the CRE-binding protein/activating...

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Identifiers

PMID: 15857826
DOI: 10.1074/jbc.M502968200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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