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Article

Pathophysiology, clinical presentation, and management of colon cancer.

Gastroenterology clinics of North America - 1 Mar 2008

Cappell Mitchell S

Abstract excerpt

Colon cancer is believed to arise from two types of precursor polyps via two distinct pathways: conventional adenomas by the conventional adenoma-to-carcinoma sequence and serrated adenomas according to the serrated adenoma-to-carcinoma theory. Conventional adenomas arise from mutation of the APC gene; progression to colon cancer is a multistep process. The fundamental genetic defect in serrated adenomas is...

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Identifiers

PMID: 18313537
DOI: 10.1016/j.gtc.2007.12.002

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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