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Article

Genetics of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis.

Advances in experimental medicine and biology - 1 Jan 2024

Grom Alexei A

Abstract excerpt

Macrophage activation syndrome (MAS) is a life-threatening episode of hyperinflammation driven by excessive activation and expansion of T cells (mainly CD8) and hemophagocytic macrophages producing proinflammatory cytokines. MAS has been reported in association with almost every rheumatic disease, but it is by far most common in systemic juvenile idiopathic arthritis (SJIA). Clinically, MAS is similar to familial...

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Share to Arthritis, Juvenile
Share to Cytokines
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Lymphohistiocytosis, Hemophagocytic

Share to Macrophages

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PMID: 39117811
DOI: 10.1007/978-3-031-59815-9_9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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