A Polymorphism in C-C Chemokine Receptor 5 (CCR5) Associates with Löfgren's Syndrome and Alters Receptor Expression as well as Functional Response.

doi:10.3390/cells10081967

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A Polymorphism in C-C Chemokine Receptor 5 (CCR5) Associates with Löfgren's Syndrome and Alters Receptor Expression as well as Functional Response.

Cells - 3 Aug 2021

Karakaya Bekir, van Moorsel Coline H M, Veltkamp Marcel, Roodenburg-Benschop Claudia, Kazemier Karin M, van der Helm-van Mil Annette H M, Huizinga Tom W J, Grutters Jan C, Rijkers Ger T

Abstract excerpt

C-C chemokine receptor 5 (CCR5) and polymorphisms in CCR5 gene are associated with sarcoidosis and Löfgren's syndrome. Löfgren's syndrome is an acute and usually self-remitting phenotype of sarcoidosis. We investigated whether the single nucleotide polymorphism (SNP) rs1799987 is associated with susceptibility for Löfgren's syndrome and has an effect on CCR5 expression on monocytes and function of CCR5. A total...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Chemokine CCL3

Share to Gene Expression

Share to Gene Frequency

Share to Monocytes

Share to Receptors, CCR5

Share to Sarcoidosis

Source

Open in PubMed Open full text

Identifiers

PMID: 34440736
DOI: 10.3390/cells10081967
PMCID: PMC8394428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Polymorphism in C-C Chemokine Receptor 5 (CCR5) Associates with Löfgren's Syndrome and Alters Receptor Expression as well as Functional Response.PMID 34440736Read ↗

Female-specific association of C-C chemokine receptor 5 gene polymorphisms with Löfgren's syndrome.Semantic proximity Read ↗

Unraveling genetic mysteries: phenotype-shaping profiles in chronic sarcoidosisSemantic proximity Read ↗

Whole-exome sequencing identifies rare genetic variations in German families with pulmonary sarcoidosis.Semantic proximity Read ↗

C-C chemokine receptor 5 gene variants in relation to lung disease in sarcoidosis.Semantic proximity Read ↗

Evaluation of genetic risk, its clinical manifestation and disease management based on 18 susceptibility gene markers among West-Slavonic patients with sarcoidosis.Semantic proximity Read ↗

ANXA11 rs1049550 Associates with Löfgren's Syndrome and Chronic Sarcoidosis Patients.Semantic proximity Read ↗

High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.Semantic proximity Read ↗

Whole Exome Sequencing Identified Two Single Nucleotide Polymorphisms of Human Leukocyte Antigen-DRB5 in Familial Sarcoidosis in China.Semantic proximity Read ↗

The MCP-1-2518 (A to G) single nucleotide polymorphism in Czech patients with pulmonary sarcoidosis: association with Löfgren's syndrome.Semantic proximity Read ↗

Sex differences in the genetics of sarcoidosis across European and African ancestry populationsSemantic proximity Read ↗

Susceptibility to leprosy is associated with M-ficolin polymorphisms.Semantic proximity Read ↗

Variation in IL7R predisposes to sarcoid inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.