Article
Angiotensin-converting enzyme 2 (ACE2) haplotypes are associated with pulmonary disease phenotypes in sarcoidosis patients.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG - 1 Oct 2005
Kruit Adrian, Ruven Henk J T, Grutters Jan C, van den Bosch Jules M M
Abstract excerpt
BACKGROUND AND AIM OF THE STUDY: Angiotensin II (Ang II) formation by angiotensin-converting enzyme (ACE) or other enzymes has shown to exhibit profibrotic properties in a variety of fibrotic diseases. A homologue of ACE called ACE2 has been shown to counteract the formation of Ang II. Genetic variation in the components involved in Ang II formation may underlie the progression of pulmonary sarcoidosis. METHOD:...
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