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Article

Deep sequencing of BCR-ABL1 kinase domain mutations in chronic myeloid leukemia patients with resistance to tyrosine kinase inhibitors.

Leukemia & lymphoma - 1 Jan 2019

Erbilgin Yucel, Eskazan Ahmet Emre, Hatirnaz Ng Ozden, Salihoglu Ayse, Elverdi Tugrul, Firtina Sinem, Tasar Orcun, Mercan Sevcan, Sisko Sinem, Khodzhaev Khusan, Ongoren Seniz, Ar Muhlis Cem, Baslar Zafer, Soysal Teoman, Sayitoglu Muge, Ozbek Ugur

Abstract excerpt

Tyrosine kinase inhibitor (TKI) therapy is the current treatment of choice for patients with chronic phase chronic myeloid leukemia (CML) leading to rapid and durable hematological as well as molecular responses. However, emergence of resistance to TKIs has been the major obstacle to treatment success on long term. In this regard kinase domain mutations are the most common mechanism of therapy failure. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29965782
DOI: 10.1080/10428194.2018.1473573

Genes

ABL1
BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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