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Article

Genomic analysis of inherited breast cancer among Palestinian women: Genetic heterogeneity and a founder mutation in TP53.

International journal of cancer - 15 Aug 2017

Lolas Hamameh Suhair, Renbaum Paul, Kamal Lara, Dweik Dima, Salahat Mohammad, Jaraysa Tamara, Abu Rayyan Amal, Casadei Silvia, Mandell Jessica B, Gulsuner Suleyman, Lee Ming K, Walsh Tom, King Mary-Claire, Levy-Lahad Ephrat, Kanaan Moein

Abstract excerpt

Breast cancer among Palestinian women has lower incidence than in Europe or North America, yet is very frequently familial. We studied genetic causes of this familial clustering in a consecutive hospital-based series of 875 Palestinian patients with invasive breast cancer, including 453 women with diagnosis by age 40, or with breast or ovarian cancer in a mother, sister, grandmother or aunt ("discovery series");...

Read the complete abstract on PubMed

Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Genetic Association Studies

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Share to Mutation, Missense

Share to Sequence Analysis, DNA

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 28486781
DOI: 10.1002/ijc.30771
PMCID: PMC5526459

Genes

BRCA1
ATM
BARD1
BRCA2
BRIP1
CHEK2
PALB2
PTEN
XRCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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