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Article

Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1.

The Journal of investigative dermatology - 1 Aug 2008

Viglio Simona, Zoppi Nicoletta, Sangalli Antonella, Gallanti Angelo, Barlati Sergio, Mottes Monica, Colombi Marina, Valli Maurizia

Abstract excerpt

Mutations in the genes encoding for type V collagen have been found in the classical type of Ehlers-Danlos syndrome (EDS); the most common mutations lead to a non-functional COL5A1 allele. We characterized three skin fibroblast strains derived from patients affected by classical EDS caused by COL5A1 haploinsufficiency. As a typical clinical hallmark of EDS is the impaired wound healing, we analyzed the repair...

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Identifiers

PMID: 18305566
DOI: 10.1038/jid.2008.33

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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