Phenotypic correction of the defective fibronectin extracellular matrix of Ehlers-Danlos syndrome fibroblasts.

doi:10.1016/0309-1651(91)90090-6

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Article

Phenotypic correction of the defective fibronectin extracellular matrix of Ehlers-Danlos syndrome fibroblasts.

Cell biology international reports - 1 Dec 1991

Barlati S, Moro L, Gardella R, Colombi M

Abstract excerpt

In vitro cultured skin fibroblasts derived from Ehlers-Danlos Syndrome (EDS) type I to VIII patients lack fibronectin-containing extracellular matrix (FN-ECM) which can be restored when EDS cells are cocultivated over a feeder of control fibroblasts. Further analysis, focused on EDS types III and...

Topics

Cells, Cultured
Ehlers-Danlos Syndrome
Extracellular Matrix
Fibroblasts
Fibronectins
Fluorescent Antibody Technique
Humans
Male
Phenotype
RNA Splicing
RNA, Messenger

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