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Article

Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism.

Cell host & microbe - 9 Jun 2021

Witchley Jessica N, Basso Pauline, Brimacombe Cedric A, Abon Nina V, Noble Suzanne M

Abstract excerpt

Candida albicans is a fungal component of the human gut microbiota and an opportunistic pathogen. C. albicans transcription factors (TFs), Wor1 and Efg1, are master regulators of an epigenetic switch required for fungal mating that also control colonization of the mammalian gut. We show that additional mating regulators, WOR2, WOR3, WOR4, AHR1, CZF1, and SSN6, also influence gut commensalism. Using Calling...

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Identifiers

PMID: 33915113
DOI: 10.1016/j.chom.2021.03.019
PMCID: PMC8216204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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