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Article

Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss.

International journal of cancer - 1 Jun 2008

Riemenschneider Markus J, Reifenberger Julia, Reifenberger Guido

Abstract excerpt

Deletion of the short arm of chromosome 1 is common in oligodendroglial tumors and has been identified as a powerful molecular marker for response to radio- and chemotherapy as well as favorable prognosis. Here, we investigated a series of 59 human primary gliomas for aberrations of the DIRAS3 (A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18302158
DOI: 10.1002/ijc.23409

Genes

DIRAS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18302158-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss.PMID 18302158Read ↗

Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors.Semantic proximity Read ↗

Two types of chromosome 1p losses with opposite significance in gliomasSemantic proximity Read ↗

Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene from 1p32 in oligodendroglial tumors.Semantic proximity Read ↗

1p36 is a preferential target of chromosome 1 deletions in astrocytic tumours and homozygously deleted in a subset of glioblastomasSemantic proximity Read ↗

Homozygous Deletions of the <i>CDKN2C</i>/p 18<sup>INK4C</sup> Gene on the Short Arm of Chromosome 1 in Anaplastic OligodendrogliomasSemantic proximity Read ↗

Distinction in gene expression profiles of oligodendrogliomas with and without allelic loss of 1pSemantic proximity Read ↗

No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3.Semantic proximity Read ↗

Downregulation of PRDX1 by promoter hypermethylation is frequent in 1p/19q-deleted oligodendroglial tumours and increases radio- and chemosensitivity of Hs683 glioma cells in vitro.Semantic proximity Read ↗

Transcriptional inactivation of TP73 expression in oligodendroglial tumorsSemantic proximity Read ↗

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Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker.Semantic proximity Read ↗

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