Article
Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms.
The international journal of biochemistry & cell biology - 1 Jan 2008
Gunter Jennifer H, Thomas Elaine C, Lengefeld Nadia, Kruger Sarah J, Worton Leah, Gardiner Edith M, Jones Alun, Barnett Nigel L, Whitehead Jonathan P
Abstract excerpt
In mammals there are two ubiquitous, catalytically indistinguishable isoforms of inosine monophosphate dehydrogenase and mutations in the type I isoform, but not type II, cause retina-specific disorders. We have characterised the spatio-temporal expression of these proteins during development of the rat retina and performed functional investigations of the recently described retinal type I variants. Inosine...
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