Article
Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho(-/-) mice.
Human molecular genetics - 1 Mar 2002
Kennan Avril, Aherne Aileen, Palfi Arpad, Humphries Marian, McKee Alex, Stitt Alan, Simpson David A C, Demtroder Karin, Orntoft Torben, Ayuso Carmen, Kenna Paul F, Farrar G Jane, Humphries Pete
Abstract excerpt
Comparative analysis of the transcriptional profiles of approximately 6000 genes in the retinas of wild-type mice with those carrying a targeted disruption of the rhodopsin gene was undertaken by microarray analysis. This revealed a series of transcripts, of which some were derived from genes known to map at retinopathy loci, levels of which were reduced or elevated in the retinas of Rho(-/-) mice lacking...
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