Article
Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast.
Genes & development - 1 Oct 1997
Polymenis M, Schmidt E V
Abstract excerpt
The eukaryotic cell cycle is driven by a cascade of cyclins and kinase partners including the G1 cyclin Cln3p in yeast. As the first step in this cascade, Cln3p is uniquely positioned to determine the critical growth-rate threshold for division. To analyze factors regulating CLN3 expression, we identified a short upstream open reading frame (uORF) in the 5' leader of CLN3 mRNA as a translational control element....
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