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Article

Role of P-glycoprotein in evolution of populations of chronic myeloid leukemia cells treated with imatinib

1 Jan 2008

Abstract excerpt

Imatinib mesylate (imatinib) is a new generation preparation that is now successfully used for treatment of cancer, particularly for chemotherapy of chronic myeloid leukemia (CML). Imatinib inhibits the activity of chimeric kinase BCR-ABL, which is responsible for the development of CML. The goal of this study was to investigate the role of a multidrug resistance protein, P-glycoprotein (Pgp), in the evolution of...

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PMID: 18294126
DOI: 10.1134/s0006297908010045

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