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Article

Structural lability in stem-loop 1 drives a 5' UTR-3' UTR interaction in coronavirus replication.

Journal of molecular biology - 28 Mar 2008

Li Lichun, Kang Hyojeung, Liu Pinghua, Makkinje Nick, Williamson Shawn T, Leibowitz Julian L, Giedroc David P

Abstract excerpt

The leader RNA of the 5' untranslated region (UTR) of coronaviral genomes contains two stem-loop structures denoted SL1 and SL2. Herein, we show that SL1 is functionally and structurally bipartite. While the upper region of SL1 is required to be paired, we observe strong genetic selection against viruses that contain a deletion of A35, an extrahelical nucleotide that destabilizes SL1, in favor of genomes that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18289557
DOI: 10.1016/j.jmb.2008.01.068
PMCID: PMC2652258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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