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Article

In vitro gender differences in neuronal survival on hypoxia and in 17beta-estradiol-mediated neuroprotection.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Apr 2005

Heyer Andrea, Hasselblatt Martin, von Ahsen Nicolas, Häfner Heinz, Sirén Anna-Leena, Ehrenreich Hannelore

Abstract excerpt

Gender differences in neuropsychiatric disease are recognized but not well understood. Investigating the survival of primary rat hippocampal neurons in culture, we found significant and inverted gender differences on normoxia versus hypoxia. Male cells were more resistant under normoxia but more vulnerable under hypoxia than female cells. Male vulnerability pattern was acquired in cells from neonatally...

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Identifiers

PMID: 15689954
DOI: 10.1038/sj.jcbfm.9600056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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