Article
Effects of pregnancy on CYP3A and P-glycoprotein activities as measured by disposition of midazolam and digoxin: a University of Washington specialized center of research study.
Clinical pharmacology and therapeutics - 1 Aug 2008
Hebert M F, Easterling T R, Kirby B, Carr D B, Buchanan M L, Rutherford T, Thummel K E, Fishbein D P, Unadkat J D
Abstract excerpt
The objectives of the study were to evaluate the effects of pregnancy on CYP3A and P-glycoprotein (P-gp) activities, as measured by disposition of midazolam and digoxin, respectively. Thirteen women received digoxin (0.25 mg p.o.) and midazolam (2 mg p.o.) in random order, separated by 1-2 weeks at 28-32 weeks gestation, and the same order was repeated at 6-10 weeks postpartum. Plasma and urine concentrations...
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