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Article

Unclassified variants in BRCA genes: guidelines for interpretation.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jan 2011

Radice P, De Summa S, Caleca L, Tommasi S

Abstract excerpt

In the last few years, several studies have focused on the interpretation of unclassified variants (UVs) of BRCA1 and BRCA2 genes. Analysis of UVs through a unique approach is not sufficient to understand their role in the development of tumors. Thus, it is clear that assembling results from different sources (genetic and epidemiological data, histopathological features, and in vitro and in silico analyses)...

Topics

Breast Neoplasms
Data Interpretation, Statistical
Female
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Genetic Testing
Genetic Variation
Guidelines as Topic
Humans
Ovarian Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Source

Identifiers

PMID: 21285146
DOI: 10.1093/annonc/mdq661

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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