Article
Correlation of epigenetic change and identification of risk factors for oral submucous fibrosis.
The International journal of biological markers - 27 Dec 2012
Xu Chunjiao, Zhao Jing, Loo Wings T Y, Hao Liang, Wang Min, Cheung Mary N B, Dou Yiding, Yip Adrian Y S, Ng Elizabeth L Y, Chow Louis W C, Liu Qing
Abstract excerpt
BACKGROUND: DNA methylation of certain genes is an epigenetic change that is essential for tumorigenesis. Oral submucous fibrosis (OSF) is a precancerous condition of oral mucosa with inflammation and progressive fibrosis of the lamina propria and deeper connective tissue. The hypermethylation of E-cadherin and cyclooxygenase 2 (COX-2) in chronic inflammation may demonstrate a mild lesion/mutation at epigenetic...
Topics
- Adult
- Aged
- Cadherins
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cyclooxygenase 2
- DNA Methylation
- Epigenesis, Genetic
- Female
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Humans
- Male