Article
Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome.
Clinical immunology (Orlando, Fla.) - 1 Apr 2008
Du Liping, Yang Peizeng, Hou Shengping, Lin Xiaomin, Zhou Hongyan, Huang Xiangkun, Wang Li, Kijlstra Aize
Abstract excerpt
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), a critical negative regulator of the T cell response, has been shown to be associated with a variety of autoimmune diseases. In this study, we investigated the association of CTLA-4 gene polymorphisms (- 1661A/G; - 318C/T; + 49G/A, and CT60) with Vogt-Koyanagi-Harada (VKH) syndrome in Chinese Han patients and normal controls. The results showed that the...
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