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Replication of Genome-Wide Association Analysis Identifies New Susceptibility Loci at Long Noncoding RNA Regions for Vogt-Koyanagi-Harada Disease.

Investigative ophthalmology & visual science - 1 Nov 2019

Qi Jian, Du Liping, Deng Jing, Qin Yang, Su Guannan, Hou Shengping, Lv Meng, Zhang Qi, Kijlstra Aize, Yang Peizeng

Abstract excerpt

Purpose: This study was aimed at investigating the association of long noncoding RNA (lncRNA)-related single nucleotide polymorphisms (SNPs) with Vogt-Koyanagi-Harada (VKH) disease. Methods: LncRNA-related SNPs were selected by multi-omics analysis. Genotyping, expression of lncRNA and mRNA, cell proliferation, and cytokine production were tested by MassARRAY System, real-time PCR, CCK8, and ELISA. Results: A...

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PMID: 31747682
DOI: 10.1167/iovs.19-27708

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