Article
Influence of HLA-DRB1 gene variation on the clinical course of Vogt-Koyanagi-Harada disease.
Investigative ophthalmology & visual science - 1 Feb 1994
Islam S M, Numaga J, Matsuki K, Fujino Y, Maeda H, Masuda K
Abstract excerpt
PURPOSE: To investigate the difference, if any, in the immunogenetic backgrounds between two clinical subtypes of Vogt-Koyanagi-Harada disease (VKH). METHODS: HLA-DR4 gene variations were investigated in 46 Japanese patients, 28 with the prolonged type and 18 with the nonprolonged type of VKH. HLA-DR4 genes were amplified with polymerase chain reaction (PCR) and then analyzed for its variation with single-strand...
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