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Article

JAK1, but not JAK2 and STAT3, confers susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population.

Investigative ophthalmology & visual science - 9 May 2013

Hu Ke, Hou Shengping, Li Fuzhen, Xiang Qin, Kijlstra Aize, Yang Peizeng

Abstract excerpt

PURPOSE: Janus kinase 1 (JAK1), JAK2, and signal transducer and activator of transcription 3 (STAT3) play an important role in Th1 and Th17 differentiation and gene polymorphisms of these factors have been demonstrated to be associated with certain autoimmune diseases. The present study was performed to assess the association between JAK1, JAK2, and STAT3 polymorphisms and Vogt-Koyanagi-Harada (VKH) syndrome in a...

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Source

Identifiers

PMID: 23611997
DOI: 10.1167/iovs.13-11615

Genes

JAK1
JAK2
STAT3

Provenance

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