Article
Phenotypic changes in influenza-specific CD8+ T cells after immunization of children and adults with influenza vaccines.
The Journal of infectious diseases - 15 Mar 2008
He Xiao-Song, Holmes Tyson H, Mahmood Kutubuddin, Kemble George W, Dekker Cornelia L, Arvin Ann M, Greenberg Harry B
Abstract excerpt
The effect of trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV) on the phenotypes of circulating influenza-specific CD8+ T cells was analyzed by interferon (IFN)-gamma flow cytometry and tetramer staining. In adults, the expression of the T cell differentiation marker CD27 on virus-specific CD8+ T cells decreased after LAIV but increased after TIV. In children, expression...
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