Article
A robust protein host for anchoring chelating ligands and organocatalysts.
Chembiochem : a European journal of chemical biology - 3 Mar 2008
Reetz Manfred T, Rentzsch Martin, Pletsch Andreas, Taglieber Andreas, Hollmann Frank, Mondière Régis J G, Dickmann Norbert, Höcker Birte, Cerrone Simona, Haeger Michaela C, Sterner Reinhard
Abstract excerpt
In order to put the previously proposed concept of directed evolution of hybrid catalysts (proteins that harbor synthetic transition-metal catalysts or organocatalysts) into practice, several prerequisites must be met. The availability of a robust host protein that can be expressed in sufficiently large amounts, and that can be purified in a simple manner is crucial. The thermostable enzyme tHisF from Thermotoga...
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