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Article

Dissection of a (betaalpha)8-barrel enzyme into two folded halves.

Nature structural biology - 1 Jan 2001

Höcker B, Beismann-Driemeyer S, Hettwer S, Lustig A, Sterner R

Abstract excerpt

The (betaalpha)8-barrel, which is the most frequently encountered protein fold, is generally considered to consist of a single structural domain. However, the X-ray structure of the imidazoleglycerol phosphate synthase (HisF) from Thermotoga maritima has identified it as a (betaalpha) 8-barrel made up of two superimposable subdomains (HisF-N and HisF-C). HisF-N consists of the four N-terminal (betaalpha) units...

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PMID: 11135667
DOI: 10.1038/83021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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