Article
Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.
Neuro-oncology - 9 Oct 2018
Claus Elizabeth B, Cornish Alex J, Broderick Peter, Schildkraut Joellen M, Dobbins Sara E, Holroyd Amy, Calvocoressi Lisa, Lu Lingeng, Hansen Helen M, Smirnov Ivan, Walsh Kyle M, Schramm Johannes, Hoffmann Per, Nöthen Markus M, Jöckel Karl-Heinz, Swerdlow Anthony, Larsen Signe Benzon, Johansen Christoffer, Simon Matthias, Bondy Melissa, Wrensch Margaret, Houlston Richard S, Wiemels Joseph L
Abstract excerpt
Background: Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31. Methods: To identify a susceptibility locus for meningioma, we conducted a meta-analysis of 2 GWAS, imputed using a merged reference panel from...
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