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Article

Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression.

Molecular psychiatry - 1 Jun 2009

Neff C D, Abkevich V, Packer J C L, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi W S, Kroeger P E, Metzger R E, Gutin A, Skolnick M H, Shattuck D, Katz D A

Abstract excerpt

The HTR1A -1019C>G genotype was associated with major depression in the Utah population. Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the HTR1A -1019G allele revealed a linkage peak on chromosome 10 (maximum HLOD=4.4). Sequencing of all known genes in the linkage region revealed disease-segregating single-nucleotide polymorphisms (SNPs) in LHPP....

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Share to Chromosomes, Human, Pair 10
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Serotonin, 5-HT1A

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Source

Identifiers

PMID: 18268499
DOI: 10.1038/mp.2008.8

Genes

LHPP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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