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Genome-wide gene-gene interaction of the 5-HTTLPR promoter polymorphism emphasizes the important role of neuroplasticity in depression.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Dec 2022

Garvert Linda, Kirchner Kevin, Grabe Hans J, Van der Auwera Sandra

Abstract excerpt

Recent genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms affecting depressive disorders. GWAS results support the heterogeneity of depression as a disorder affected by a large number of genetic variants with mainly small effect sizes. However, not much is known about the interplay of different genetic risk factors. Moreover, recent studies are questioning the role of...

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PMID: 35977647
DOI: 10.1016/j.pnpbp.2022.110614

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