Article
Association between conformational mutations in neuroserpin and onset and severity of dementia.
Lancet (London, England) - 29 Jun 2002
Davis Richard L, Shrimpton Antony E, Carrell Robin W, Lomas David A, Gerhard Lieselotte, Baumann Bruno, Lawrence Daniel A, Yepes Manuel, Kim Tai Seung, Ghetti Bernardino, Piccardo Pedro, Takao Masaki, Lacbawan Felicitas, Muenke Maximilian, Sifers Richard N, Bradshaw Charles B, Kent Paul F, Collins George H, Larocca Daria, Holohan Peter D
Abstract excerpt
BACKGROUND: The aggregation of specific proteins is a common feature of the familial dementias, but whether the formation of neuronal inclusion bodies is a causative or incidental factor in the disease is not known. To clarify this issue, we investigated five families with typical neuroserpin inclusion bodies but with various neurological manifestations. METHODS: Five families with neurodegenerative disease and...
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