Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses.

doi:10.1016/j.jaci.2006.08.006

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Article

Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses.

The Journal of allergy and clinical immunology - 1 Dec 2006

McDonald Douglas R, Brown Daniel, Bonilla Francisco A, Geha Raif S

Abstract excerpt

BACKGROUND: Engagement of all known Toll-like receptors (TLRs) causes the production of inflammatory cytokines, including TNF-alpha, whereas in humans, engagement of TLRs 3, 7, 8, and 9 also induces type I IFNs. IRAK-4 is a critical effector in signaling by TLRs and the IL-1 receptor, which share homology in their intracellular domain and recruit IRAK-4 via the adaptor myeloid differentiation factor 88 (MyD88)....

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Topics

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Share to Down-Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

Share to Toll-Like Receptors

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Source

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Identifiers

PMID: 17157666
DOI: 10.1016/j.jaci.2006.08.006

Genes

TNF
TLR3
TLR7
TLR8
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.