Article
Variation and heritability of Hb F and F-cells among beta-thalassemia heterozygotes in Hong Kong.
American journal of hematology - 1 Jun 2008
Gibney Geoffrey T, Panhuysen Carolien I M, So Jason C C, Ma Edmond S K, Ha Shau Yin, Li Chi Kong, Lee Anselm C W, Li Chi Keung, Yuen Hui Leung, Lau Yu Lung, Johnson David M, Farrell John J, Bisbee Alice B, Farrer Lindsay A, Steinberg Martin H, Chan Li Chong, Chui David H K
Abstract excerpt
Enhanced fetal hemoglobin (Hb F) production can partially compensate for the lack of adult hemoglobin (Hb A) in patients with beta-thalassemia major or intermedia, and ameliorate the clinical severity of these diseases. To further elucidate factors governing Hb F levels, we evaluated demographic, clinical, laboratory, and genetic characteristics in 241 unrelated adult beta-thalassemia carriers in Hong Kong. They...
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