Article
A comparison of the cell lines used in meningioma research.
Surgical neurology - 1 Sept 2008
Ragel Brian T, Couldwell William T, Gillespie David L, Wendland Merideth M, Whang Kum, Jensen Randy L
Abstract excerpt
BACKGROUND: Immortal cell lines and cell lines derived from operative specimens transplanted into animal models are used in meningioma research. We address 2 criticisms of the mouse xenograft flank tumor model: Why are tumor induction rates derived from operative specimens low and inconsistent? Are flank tumors meningiomas? METHODS: Meningioma cell cultures were processed for Giemsa-band karyotyping and flow...
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