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Article

A highly conserved 310 helix within the kinesin motor domain is critical for kinesin function and human health.

Science advances - 1 Apr 2021

Lam Aileen J, Rao Lu, Anazawa Yuzu, Okada Kyoko, Chiba Kyoko, Dacy Mariah, Niwa Shinsuke, Gennerich Arne, Nowakowski Dan W, McKenney Richard J

Abstract excerpt

KIF1A is a critical cargo transport motor within neurons. More than 100 known mutations result in KIF1A-associated neurological disorder (KAND), a degenerative condition for which there is no cure. A missense mutation, P305L, was identified in children diagnosed with KAND, but the molecular basis for the disease is unknown. We find that this conserved residue is part of an unusual 310 helix immediately adjacent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33931448
DOI: 10.1126/sciadv.abf1002
PMCID: PMC8087401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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